7501 results
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
auricular papules Clinical ... disease and ILD • Liver ... Liver biopsies show ... steatosis and hepatocyte
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... Synthesis: in hepatocyte
Pathology - Hepatocyte Pigments

Lipofuschin (H&E) 

Alpha-I-antitrypsin globules (PAS-D) 

Mallory's hyaline / Mallory Denk Bodies 

Giant Mitochondria
Pathology - Hepatocyte ... bilirubinostasis (H&E) #Hepatocyte ... Pathology #Hepatology #Clinical
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
nonalcoholic fatty liver ... features of NASH in liver-biopsy ... specimens: ballooned hepatocytes ... cirrhosis, and primary liver
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... infiltrates maternal hepatocytes ... → Liver dysfunction ... malaise) → Acute liver ... Maternal Support - Critical
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Findings in Hepatic / Liver ... fold with acute liver ... permanent loss of hepatocytes ... ; in chronic liver ... has exhausted liver
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
The Liver Consult ... Focus on prior Liver ... MELD - Chronic liver ... disease work up - Liver ... US - Prior liver
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
other routes of liver ... the extent of hepatocyte
Hepatic Portal Venous System Drainage Anatomy
1) Most of the blood from abdominal organs goes into the
is delivered to hepatocytes