113 results
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... Synthesis: in hepatocyte
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
nonalcoholic fatty liver ... features of NASH in liver-biopsy ... specimens: ballooned hepatocytes ... cirrhosis, and primary liver ... HCC #Prevalence #NEJM
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte ... siRNA #Therapy #NEJM
Goal-Directed Therapy - Evidence Summary of Major Clinical Trials

 - EGDT: NEJM 2001

 - ProCESS: NEJM
Trials - EGDT: NEJM ... - ProCESS: NEJM ... 2014 - ARISE: NEJM ... - ProMlSe: NEJM ... Therapy #Trials #EBM
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... NonAlcoholicFattyLiverDisease #NEJM
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
Care TRICC - NEJM ... - ICU FOCUS - NEJM ... UGIB TRISS - NEJM ... Blood saves lives ... /vmoitra) #EBM
PCI in Acute MI with Cardiogenic Shock. #EBM #Cardiology #CULPRITSHOCK #PCI #VisualAbstract #NEJM
#EBM #Cardiology ... VisualAbstract #NEJM
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... infiltrates maternal hepatocytes ... → Liver dysfunction ... malaise) → Acute liver ... Transfer to a liver
A Controlled Trial of Erenumab for Episodic Migraine #EBM #Neuro #Erenumab #Migraine #CGRP #VisualAbstract #NEJM
Episodic Migraine #EBM ... VisualAbstract #NEJM
Trial of Solanezumab for Mild Dementia Due to Alzheimers Disease #EBM #Dementia #Solanezumab #Alzheimers #NegativeTrial #VisualAbstract
Alzheimers Disease #EBM ... VisualAbstract #NEJM