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diagnosis hematology differential algorithm management causes liver anemia treatment cirrhosis pathophysiology clinical workup oncology thrombocytopenia anticoagulation gastroenterology syndrome table pharmacology
NAFLD Activity Score (NAS) 0–3 for steatosis 0–3 for inflammation 0–2 for ballooning hepatocytes NAS ≥5 is classified as definitive
NAFLD Activity Score ... for ballooning hepatocytes ... .2020.603926 #NAFLD ... NAS #diagnosis #hepatology
NAFLD / NASH Progression Timeline Healthy Liver → NAFLD/NASH → 0.25-3.2%/year → Cirrhotic NASH → 0.3-2.6%/year →
NAFLD / NASH Progression ... Healthy Liver → NAFLD ... /year → HCC • NAFLD ... Polymorphisms, Age #NAFLD ... Progression #Timeline #hepatology
Pathology - Hepatocyte Pigments Lipofuschin (H&E) Alpha-I-antitrypsin globules (PAS-D) Mallory's hyaline / Mallory Denk Bodies Giant Mitochondria
Pathology - Hepatocyte ... bilirubinostasis (H&E) #Hepatocyte ... Pigments #Pathology #Hepatology
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... #GI #IM #NASH #NAFLD
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
liver disease (NAFLD ... specimens: ballooned hepatocytes ... Epidemiology #NASH #NAFLD
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Synthesis: in hepatocyte ... accumulation in hepatocyte ... conjugation in hepatocyte ... reuptake into hepatocyte ... AlkPhos #Bilirubin #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Hemochromatosis • NAFLD ... ALT < 5x ULN • NAFLD ... Others #LFTs #Hepatology
Non-alcoholic fatty liver disease algorithm. For those patients with NAFLD or liver disease of unknown aetiology,
patients with NAFLD ... calculation of a FIB4 or NAFLD ... disease; NFS, NAFLD ... FattyLiver #Disease #NAFLD ... Referral #Management #Hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Wilson's, HH, NAFLD ... 5x ULN - NAFLD ... Algorithm #diagnosis #hepatology
Hepatic Portal Venous System Drainage Anatomy 1) Most of the blood from abdominal organs goes into the
is delivered to hepatocytes ... Pathophysiology #Hepatology
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