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diagnosis testing differential management hepatology algorithm hematology interpretation rheumatology disease workup liver table clinical comparison covid19 causes coagulation tests treatment
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Synthesis: in hepatocyte ... accumulation in hepatocyte ... conjugation in hepatocyte ... reuptake into hepatocyte ... Chemistry #Tests #Laboratory
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... #GI #IM #NASH #NAFLD
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
liver disease (NAFLD ... specimens: ballooned hepatocytes ... Epidemiology #NASH #NAFLD
NAFLD / NASH Progression Timeline Healthy Liver → NAFLD/NASH → 0.25-3.2%/year → Cirrhotic NASH → 0.3-2.6%/year →
NAFLD / NASH Progression ... Healthy Liver → NAFLD ... /year → HCC • NAFLD ... Polymorphisms, Age #NAFLD
Pathology - Hepatocyte Pigments Lipofuschin (H&E) Alpha-I-antitrypsin globules (PAS-D) Mallory's hyaline / Mallory Denk Bodies Giant Mitochondria
Pathology - Hepatocyte ... bilirubinostasis (H&E) #Hepatocyte
Non-alcoholic fatty liver disease algorithm. For those patients with NAFLD or liver disease of unknown aetiology,
patients with NAFLD ... calculation of a FIB4 or NAFLD ... hepatocellular carcinoma; NAFLD ... disease; NFS, NAFLD ... FattyLiver #Disease #NAFLD
Assessment of Nonalcoholic Steatohepatitis (NASH) Severity in Patients With Nonalcoholic Fatty #Diagnosis #Pathology #NAFLD #NASH #Fibrosis #Staging
Diagnosis #Pathology #NAFLD
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte
NAFLD Activity Score (NAS) 0–3 for steatosis 0–3 for inflammation 0–2 for ballooning hepatocytes NAS ≥5 is classified as definitive
NAFLD Activity Score ... for ballooning hepatocytes ... .2020.603926 #NAFLD
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Hemochromatosis • NAFLD ... ALT < 5x ULN • NAFLD
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