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clinical hepatology ultrasound diagnosis liver algorithm differential transaminitis abnormal abscess blood calling consultation gastric gastroenterology giconsult nash nejm nonalcoholicfattyliverdisease nonalcoholicsteatohepatitis
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Synthesis: in hepatocyte ... accumulation in hepatocyte ... conjugation in hepatocyte ... reuptake into hepatocyte ... Pathophysiology #Diagnosis #LFTs
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... #GI #IM #NASH #NAFLD
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
liver disease (NAFLD ... specimens: ballooned hepatocytes ... Epidemiology #NASH #NAFLD
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... 100-500): • NAFLD ... Function #Tests #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Hemochromatosis • NAFLD ... ALT < 5x ULN • NAFLD ... • Others #LFTs
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Wilson's, HH, NAFLD ... 5x ULN - NAFLD ... Burak @kwburak #LFTs
NAFLD Activity Score (NAS) 0–3 for steatosis 0–3 for inflammation 0–2 for ballooning hepatocytes NAS ≥5 is classified as definitive
NAFLD Activity Score ... for ballooning hepatocytes ... .2020.603926 #NAFLD
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
antitrypsin • Other: NAFLD ... Transaminitis #LFTs
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
a diagnosis of NAFLD ... dehydrogenase; NAFLD ... #LFTs #Abnormal
Liver Abscess on POCUS 24yo healthy F to ED w/rigors &DCed. 2/2 blood cx + for fusobacterium,
Liver Abscess on POCUS ... asymptomatic, CBC/chem/LFTs ... Abscess #Hepatic #POCUS
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