25 results
An Approach to Jaundice Workup Algorithm by CBC and LFT Pattern

- Dr. Eric Strong @DrEricStrong

#Jaundice #Workup
Approach to Jaundice Workup ... Algorithm by CBC and LFT ... DrEricStrong #Jaundice #Workup ... Algorithm #Patterns #LFTs
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Synthesis: in hepatocyte ... accumulation in hepatocyte ... conjugation in hepatocyte ... reuptake into hepatocyte ... Pathophysiology #Diagnosis #LFTs
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... #GI #IM #NASH #NAFLD
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
liver disease (NAFLD ... specimens: ballooned hepatocytes ... Epidemiology #NASH #NAFLD
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Function Tests (LFTs ... 100-500): • NAFLD ... Function #Tests #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Hemochromatosis • NAFLD ... ALT < 5x ULN • NAFLD ... • Others #LFTs
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Wilson's, HH, NAFLD ... 5x ULN - NAFLD ... Burak @kwburak #LFTs
Differential Diagnosis of Jaundice, Presentation Pattern #Diagnosis #EM #IM #GI #Jaundice #Pattern #LFTs #Workup #Table #Differential
Jaundice #Pattern #LFTs ... #Workup #Table
Gynecomastia - Differential Diagnosis a
nd Workup Algorithm
Gynecomastia is common in clinical practice, affecting ~50% of males
Diagnosis a nd Workup ... Labs: TSH, Cr, LFTs ... Differential #Diagnosis #Workup
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
/uL Initial Workup ... reticulocyte count, LFTs ... Algorithm #hematology #workup