197 results
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
nonalcoholic fatty liver ... disease (NAFLD) ... specimens: ballooned hepatocytes ... cirrhosis, and primary liver ... Epidemiology #NASH #NAFLD
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... Synthesis: in hepatocyte
NAFLD / NASH Progression Timeline
Healthy Liver → NAFLD/NASH → 0.25-3.2%/year → Cirrhotic NASH → 0.3-2.6%/year →
NAFLD / NASH Progression ... Timeline Healthy Liver ... → NAFLD/NASH → ... /year → HCC • NAFLD ... Polymorphisms, Age #NAFLD
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
Non-alcoholic fatty liver ... patients with NAFLD ... or liver disease ... likelihood of liver ... ELF, enhanced liver
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... #GI #IM #NASH #NAFLD
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Hemochromatosis • NAFLD ... ALT < 5x ULN • NAFLD ... Diagnosis #Algorithm #Causes
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Hepatocellular - Liver ... Antitrypsin • Other: NAFLD ... Differential #Diagnosis #Causes
NAFLD Activity Score (NAS)
0–3 for steatosis
0–3 for inflammation
0–2 for ballooning hepatocytes
NAS ≥5 is classified as definitive
NAFLD Activity Score ... for ballooning hepatocytes ... a simple fatty liver ... .2020.603926 #NAFLD
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... 100-500): • NAFLD ... (Drug-induced liver ... Hepatopathy (shock liver ... LouLectures #Liver
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
Causes of Hyperferritinemia ... leaving enterocytes, hepatocytes ... is made in the liver ... Most Common Causes ... 1% Most Common Causes