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diagnosis hepatology clinical algorithm radiology differential lfts nash ct nonalcoholic photo disease pathophysiology causes fatty fattyliver pathology progression transaminitis abnormal
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
nonalcoholic fatty liver ... disease (NAFLD) ... specimens: ballooned hepatocytes ... Epidemiology #NASH #NAFLD ... HCC #Prevalence #NEJM
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... #GI #IM #NASH #NAFLD ... NonAlcoholicFattyLiverDisease #NEJM
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... Synthesis: in hepatocyte
NAFLD / NASH Progression Timeline Healthy Liver → NAFLD/NASH → 0.25-3.2%/year → Cirrhotic NASH → 0.3-2.6%/year →
NAFLD / NASH Progression ... Timeline Healthy Liver ... → NAFLD/NASH → ... /year → HCC • NAFLD ... Polymorphisms, Age #NAFLD
Non-alcoholic fatty liver disease algorithm. For those patients with NAFLD or liver disease of unknown aetiology,
Non-alcoholic fatty liver ... patients with NAFLD ... or liver disease ... likelihood of liver ... ELF, enhanced liver
NAFLD Activity Score (NAS) 0–3 for steatosis 0–3 for inflammation 0–2 for ballooning hepatocytes NAS ≥5 is classified as definitive
NAFLD Activity Score ... for ballooning hepatocytes ... a simple fatty liver ... .2020.603926 #NAFLD
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... 100-500): • NAFLD ... (Drug-induced liver ... Hepatopathy (shock liver ... LouLectures #Liver
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte ... siRNA #Therapy #NEJM
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Hemochromatosis • NAFLD ... ALT < 5x ULN • NAFLD
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Wilson's, HH, NAFLD ... 5x ULN - NAFLD
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