25 results
Histologic Features and Prevalence of Nonalcoholic Steatohepatitis (NASH). NASH is a potentially progressive type of nonalcoholic
Steatohepatitis (NASH ... liver disease (NAFLD ... specimens: ballooned hepatocytes ... #NAFLD #NonAlcoholicSteatoHepatitis ... HCC #Prevalence #NEJM
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
develop in fatty hepatocytes ... Pathophysiology #GI #IM #NASH ... #NAFLD #NonAlcoholicSteatoHepatitis ... NonAlcoholicFattyLiverDisease #NEJM
NAFLD / NASH Progression Timeline
Healthy Liver → NAFLD/NASH → 0.25-3.2%/year → Cirrhotic NASH → 0.3-2.6%/year →
NAFLD / NASH Progression ... Healthy Liver → NAFLD ... /NASH → 0.25-3.2% ... /year → HCC • NAFLD ... Polymorphisms, Age #NAFLD
NAFLD Activity Score (NAS)
0–3 for steatosis
0–3 for inflammation
0–2 for ballooning hepatocytes
NAS ≥5 is classified as definitive
NAFLD Activity Score ... (NAS) 0–3 for steatosis ... for ballooning hepatocytes ... as definitive NASH ... .2020.603926 #NAFLD
Assessment of Nonalcoholic Steatohepatitis (NASH) Severity in Patients With Nonalcoholic Fatty
#Diagnosis #Pathology #NAFLD #NASH #Fibrosis #Staging
Steatohepatitis (NASH ... Diagnosis #Pathology #NAFLD ... #NASH #Fibrosis
The Mechanism of Small Interfering RNA (siRNA) Therapy. Synthetic double-stranded RNA containing an ALAS1-specific sequence is
exclusively on hepatocytes ... Within the hepatocyte ... siRNA #Therapy #NEJM
NASH/NAFLD - Liver Biopsy Indications Algorithm

#NASH #NAFLD #Liver #Biopsy #Indications #Algorithm #diagnosis #hepatology
NASH/NAFLD - Liver ... Algorithm #NASH ... #NAFLD #Liver #
Excoriated papules with honey-colored crusting were present on the abdomen, back (Panel A), arms, and legs.
Scabies #Microscopy #Rash ... #NEJM
Crusted Scabies - Physical examination now revealed a generalized erythematous and scaly rash with intense hyperkeratotic
erythematous and scaly rash ... Scabies #Microscopy #NEJM
NAFLD Diagnosis Algorithm
Two-step diagnostic strategy for NAFLD
1st step: 
  - Clinical biomarkers, scoring systems- FIB4,
NAFLD Diagnosis ... diagnostic strategy for NAFLD ... systems- FIB4, NAFLD ... Liver #Disease #NAFLD ... Algorithm #hepatology #NASH