17 results
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
extensive necrosis and hemorrhage ... often <5 mg/dL, higher ... #hepatitis #comparison ... #differential # ... diagnosis #icp #
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... • Reduced liver ... • Massive hemorrhage ... #diagnosis #differential
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Massive hemorrhage ... #diagnosis #differential
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... , Metastasis #Liver ... #Lesions #Hepatic ... POCUS #radiology #differential ... #diagnosis #comparison
Ruptured Tubal Ectopic Pregnancy on Pelvic Ultrasound

Young female.  Lower abdominal pain/VB.  UCG pos. Soft
Pregnancy on Pelvic Ultrasound ... Diagnosis/differential ... Answer: Pt has IUD ... assume that acute hemorrhage ... clinical #OBGyn #Obstetrics
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Diagnosis Algorithm ... phosphatase sources: - Highest ... • Bone • Liver ... Intestine - Other causes ... elevation DDX of Hepatic
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm
Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Hemorrhage - Differential ... Diagnosis Algorithm ... Anti-coagulation agents (e.g. heparin ... #Causes #Obstetrics
Postpartum Hemorrhage - Differential Diagnosis and Management 
Uterine Atony (80%) - Most PPH Will respond to
Postpartum Hemorrhage ... - Differential ... CBC, fibrinogen, PT ... compression (using ultrasound ... #obstetrics #obgyn
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... Antithrombin Ill • Ultrasound ... infiltration) Differential ... Diagnosis: Viral ... Pregnancy #hepatology #obstetrics
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... Acral cyanosis • Hemorrhagic ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... #Coagulation #diagnosis