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diagnosis causes algorithm calculation classification cold disease extravascular hemolysis index intravascular production reticulocyte testing workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Due to Viral infection ... • Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold agglutinins ... inclusions - If infection ... (oroya fever), babesia ... #Anemia #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... . primary cold agglutin ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... drug induced • Infections ... Bartonella, Babesia ... #Anemia #Differential ... classification #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
B12, Folate • Hormone ... (e.g. cancer, infection ... Microangiopathic hemolytic ... Production #Index #hematology ... #anemia #differential
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