15 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
malignancy (CLL ... malignancies - B-cell ... malignancies -> CLL ... younger pts) Differential ... significance (MGUS), CLL
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Lymphoblastic Leukemia (Pancytopenia ... Lymphocytes) - Monoclonal ... Reed-Sternberg Cells ... #Hematology #Oncology
Trunk / Sacral Skin Ulcers - Differential Diagnosis Algorithm
Neoplastic
 • Squamous cell carcinoma
 • Basal cell
Neoplastic • Squamous cell ... carcinoma • Basal cell ... fungoides (cutaneous T-cell ... lymphoma) Physical ... #dermatology #Differential
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... - infiltrates (anemia ... Phosphorus CLL ... mosquito bites CLL ... #Hematology #Oncology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
with Pancytopenia ... - Differential ... Myelofibrosis Stem cell ... Toxins • Aplastic Anemia ... #Hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Gammopathies C - HyperCalcemia ... 40 ml/min A - Anemia ... marrow plasma cell ... , B and T cell lymphoproliferative ... #oncology
Skin Ulcers by Etiology - Differential Diagnosis Algorithm
Physical:
 • Trauma
 • Pressure
 • Radiation
Vascular:
 • Arterial
: • Squamous cell ... carcinoma • Basal cell ... fungoides (cutaneous T-cell ... Hematologic: • Sickle Cell ... #dermatology #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... , lymphoma, idiopathic ... . primary cold agglutin ... Hemoglobinopathies (e.g. sickle cell ... #differential #
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Lymphocytic Leukemia (CLL ... Transformation to large cell ... lymphoma (Richter ... fludarabine) 3) Monoclonal ... uw_IMresidency #CLL
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
No evidence of anemia ... damage, such as hyperCalcemia ... insufficiency, Anemia ... to the plasma cell ... #diagnosis #oncology