9 results
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Lymphoblastic Leukemia (Pancytopenia ... Lymphocytes) - Monoclonal ... Reed-Sternberg Cells ... #Hematology #Oncology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
malignancy (CLL ... malignancies - B-cell ... malignancies -> CLL ... younger pts) Differential ... significance (MGUS), CLL
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Gammopathies C - HyperCalcemia ... 40 ml/min A - Anemia ... marrow plasma cell ... , B and T cell lymphoproliferative ... #oncology
Skin Ulcers by Etiology - Differential Diagnosis Algorithm
Physical:
 • Trauma
 • Pressure
 • Radiation
Vascular:
 • Arterial
: • Squamous cell ... carcinoma • Basal cell ... fungoides (cutaneous T-cell ... Hematologic: • Sickle Cell ... #dermatology #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... , lymphoma, idiopathic ... . primary cold agglutin ... Hemoglobinopathies (e.g. sickle cell ... #differential #
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... Weight loss • Anemia ... Immune hemolytic anemia ... Immunohistochemical studies (to differentiate ... #oncology #management
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Marginal Zone Lymphoma ... (HCV) • CLL & ... (-) hemolytic anemia ... #Monoclonal #Differential ... #Diagnosis #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Causes of Monoclonal ... myeloma • Plasma cell ... Thalassemia, Sickle cell ... anemia • Other ... Gap #ProteinGap #differential
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
Solitary Cell Plasmacytoma ... • Plasma cell neoplasms ... MM, the plasma cell ... , hypercalcemia, ... #Solitary #Cell