9 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... of Clinical Significance ... (MGUS) - Differential ... #Significance # ... #oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... of Undetermined Significance ... damage, such as hyperCalcemia ... #Significance # ... #oncology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Cancer Related • Hypercalcemia ... tubulopathy • Monoclonal ... gammopathy of renal ... significance (MGRS ... #Differential #
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma and Monoclonal ... Gammopathies C - HyperCalcemia ... 40 ml/min A - Anemia ... MGUS #diagnosis #hematology ... #oncology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... younger pts) Differential ... gammopathy of undetermined ... significance (MGUS ... #hematology #diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
it represents a monoclonal ... Causes of Monoclonal ... endocrinopathy, monoclonal ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
of Undetermined Significance ... of Undetermined Significance ... blood count with differential ... Syndromes #diagnosis #hematology ... #oncology
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
tissue composed of monoclonal ... • No CRAB - no anemia ... , hypercalcemia, ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology