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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilia ... and Hypereosinophilic ... Syndrome #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Definition: An absolute eosinophil ... attributable to eosinophilia ... confirmed tissue eosinophilia ... with blood eosinophilia ... Syndrome #HES #eosinophilia
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Eosinophilia - Differential ... Primary Eosinophilia ... : • Primary hypereosinophilic ... AI: EGPA, IgG-4 disease ... , Behcet disease
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Peripheral blood eosinophilia ... specific symptoms • Eosinophilia ... secondary causes of eosinophilia ... #eosinophilia
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Mastocytosis - Acute Eosinophilic ... Syndrome - Chronic Eosinophilic ... coyefish379 #Eosinophilia
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
Diagnosis of Pulmonary Eosinophilia ... Tropical pulmonary eosinophilia ... sting Others: • Eosinophilic ... chronic pulmonary eosinophilia ... , Hypereosinophilic
Infectious causes of eosinophilia

By Dr. Hawra Al-Lawati @hawraallawati via Febrile [febrilepodcast.com]
#ID  #Infectious Diseases  #Infections
#Differential
Infectious causes of eosinophilia ... ID #Infectious Diseases ... Ddx #Diagnosis #eosinophilia ... #eosinophil #fever
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... • Acute Eosinophilic ... SOB • Chronic Eosinophilic ... fever, rhinitis • Eosinophilic ... , CV, renal • Hypereosinophilic
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
Eosinophils (Eos ... ) and hypereosinophilia ... , IgG4-related disease ... TerrierBen #Eosinophils ... #hypereosinophilia
Secondary Causes of Esophageal Eosinophilia (EoE) - Differential Diagnosis
 • Gastroesophageal reflux disease
 • Eosinophilic gastrointestinal
of Esophageal Eosinophilia ... • Eosinophilic ... Achalasia • Hypereosinophilic ... #esophagitis #Eosinophilic ... Secondary #Causes #gastroenterology