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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
disorders • Diagnosis ... and Treatment Algorithm ... Syndrome #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Peripheral blood eosinophilia ... of eosinophilia ... #Differential #diagnosis ... #hematology #eosinophilia
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Diagnosis Algorithm ... : • Primary hypereosinophilic ... GI, lung, skin), ... #Differential #Diagnosis ... #Algorithm #allergy
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
attributable to eosinophilia ... confirmed tissue eosinophilia ... with blood eosinophilia ... Secondary Causes ... #diagnosis #hematology
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Syndrome - Chronic Eosinophilic ... coyefish379 #Eosinophilia ... #Causes #hematology
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
of Pulmonary Eosinophilia ... eosinophilia (lymphatic ... sting Others: • Eosinophilic ... eosinophilia, Hypereosinophilic ... #Diagnosis #causes
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... Lung Diseases ... • Acute Eosinophilic ... #Lung #Diseases ... #diagnosis #comparison
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
Eosinophils (Eos ... ) and hypereosinophilia ... TerrierBen #Eosinophils ... #hypereosinophilia ... #Differential #Diagnosis
Secondary Causes of Esophageal Eosinophilia (EoE) - Differential Diagnosis
 • Gastroesophageal reflux disease
 • Eosinophilic gastrointestinal
of Esophageal Eosinophilia ... • Eosinophilic ... Achalasia • Hypereosinophilic ... #esophagitis #Eosinophilic ... #gastroenterology
Interstitial Lung Diseases (ILD)
Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): 
 • Hypersensitivity pneumonitis, Farmer's lung, Bird
ILD caused by inhalation ... polyangiitis, Eosinophilic ... syndrome) • Eosinophilic ... #diagnosis #differential ... #pulmonary #causes