Hypereosinophilic eosinophils gastroenterology disease hepatology eosinophilia diagnosis hematology causes workup treatment table dermatology anemia syndrome cll management

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Hypereosinophilia and Hypereosinophilic Syndrome

• Secondary Hypereosinophilic Syndrome
• Clinically Relevant HES Variants
• When to

disorders • Diagnosis ... and Treatment Algorithm ... #Hematology #eosinophilia ... #eosinophils #diagnosis ... #management #algorithm

Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and

: An absolute eosinophil ... Secondary Causes ... #eosinophilia #diagnosis ... #hematology #differential ... #management #eosinophils

Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
• Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or

Eosinophil Disorders ... of eosinophilia ... glucocorticoid treatment ... #Differential #diagnosis ... #hematology #eosinophilia

Causes of Eosinophilia - Differential Diagnosis
Bugs:
- Fungus (aspergillosis)
- Viral (HIV)
- Ectoparasites (scabies, myiasis)

Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Syndrome - Chronic ... Eosinophilic Leukemia ... #Causes #hematology

Eosinophilic Gastroenteritis: Treatment Options Based on Severity of the Disease
Mild:
• Trial of PPI
• Trial

Eosinophilic Gastroenteritis ... Severity of the Disease ... Concern for HES: • Hematology ... scan #EoE #Eosinophilic ... #management #gastroenterology

Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells

old, ~10,000 new cases ... cytopenias (usually anemia ... Allogeneic stem cell ... #Management #treatment ... #hematology #oncology

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition:
• Severe adverse drug reaction, characterized by

Reaction with Eosinophilia ... lymphadenopathy, eosinophilia ... Eosinophilia 4 ... : symptomatic treatment ... #dermatology #diagnosis

Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear

extramedullary disease ... • (Peripheral eosinophilia ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis

Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
• Lymphocytes accumulate in large numbers

cells can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment ... #workup #oncology ... #hematology

Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years

What?
• Aplastic anemia

and petechiae Causes ... - Hepatitis, eosinophilic ... Treatment: ... #oncology #hematology ... #diagnosis #management

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