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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilia ... and Hypereosinophilic ... Syndrome #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
/hypereosinophilia ... 1,500 cells/µL • Hypereosinophilia ... symptoms (eg, skin ... #Differential #diagnosis ... #hematology #eosinophilia
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia ... with blood eosinophilia ... Secondary Causes ... Alert_Oriented3 #Hypereosinophilia ... #diagnosis #hematology
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Leukemia - Primary Hypereosinophilic ... coyefish379 #Eosinophilia ... #Causes #hematology
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
of Pulmonary Eosinophilia ... eosinophilia (lymphatic ... sting Others: • Eosinophilic ... eosinophilia, Hypereosinophilic ... #Diagnosis #causes
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Diagnosis Algorithm ... : • Primary hypereosinophilic ... GI, lung, skin), ... , Behcet disease ... #Differential #Diagnosis
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
Eosinophils (Eos ... ) and hypereosinophilia ... TerrierBen #Eosinophils ... #hypereosinophilia ... #Differential #Diagnosis
Secondary Causes of Esophageal Eosinophilia (EoE) - Differential Diagnosis
 • Gastroesophageal reflux disease
 • Eosinophilic gastrointestinal
of Esophageal Eosinophilia ... • Eosinophilic ... Achalasia • Hypereosinophilic ... #esophagitis #Eosinophilic ... #gastroenterology
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... • Acute Eosinophilic ... , CV, renal • Hypereosinophilic ... loss; CV, CNS, skin ... #diagnosis #comparison
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Causes of Leukocytosis ... - Differential Diagnosis ... • Eosinophilia ... (AEC > 500, hypereosinophilia ... #causes #hematology