6 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... nephrocalcinosis • CPPD ... collection with EDTA Pathophysiology ... Hyophosphatasia #hepatology ... #diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Algorithm Hodgkin ... lymphadenopathy more diffuse ... B-Cell ~90% • Low ... Classification #pathophysiology ... #Hematology #Diagnosis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low ... Glomerulonephritis • With associated ... #differential #diagnosis ... #algorithm #rheumatology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... activation -> diffuse ... ARVs can have low ... Diagnosis: MRI ... Brain parenchymal loss
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
arthritis, weight loss ... anti-Smith Ab, low ... Differential Diagnosis ... : • ANCA-associated ... , lymphopenia, low
Essential Thrombocythemia (ET)
ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
trimester pregnancy loss ... Demonstration of an ET-associated ... • Treatment algorithms ... appropriate only for low ... #hematology