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Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Syndrome is a rare ... recessive salt-losing ... H+ secretion → Hypokalemia ... #nephrology #diagnosis
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... hypokalemic salt-losing ... cotransporter • Gitelman's ... • Seizures • Rhabdomyolysis ... #nephrology #management
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - ... Summary Causes of Rhabdomyolysis ... - Compartment syndrome ... per day until stable ... causes #treatment #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... Clenching of fist during ... - Tumor lysis syndrome ... - Rhabdomyolysis ... potassium #high #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... Clenching of fist during ... - Tumor lysis syndrome ... - Rhabdomyolysis ... potassium #high #nephrology
Rhabdomyolysis - Differential Diagnosis Framework
Rhabdomyolysis = Destruction of skeletal muscle with leakage of contents into circulation.
Rhabdomyolysis - ... Neuroleptic malignant syndrome ... Electrolytes: Hypokalemia ... Diagnosis #Causes #nephrology ... #table
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... Torsemide) • Acute pulmonary ... Hyponatremia • Hypercalcemia ... Excretion #Diuresis #Nephrology ... #Medications #Table
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
with presence of pulmonary ... then be excreted using ... acute coronary syndrome ... cardiology #treatment #table ... heartfailure #chf #criticalcare