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diagnosis differential nephrology potassium pharmacology high acute algorithm management treatment acei arb binders binding common comparison diuresis diuretics excretion initiation
Drug-induced renal disorders - The most commonly used nephrotoxic drugs #Pharmacology #Nephrotoxicity #Drugs #Medications #Most #Common #DrugInduced
Drug-induced renal ... #Medications #Most ... #Common #DrugInduced ... #KidneyInjury #AKI ... #Table #List
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... Hyperkalemia ... Increased EC shift of K ... pharmacology #potassium #medications ... #druginduced
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Kidney Injury (AKI ... Distributive Shock, HRS, Hypercalcemia ... Compartment Syndrome, Medications ... Pigment, Protein) • AIN ... Diagnosis #nephrology #causes
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
desired serum K ... constipation, diarrhea, nausea ... ); nausea, vomiting ... #medications #pharmacology ... #table #comparison
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... reactions Common Drugs ... • Digoxin • K ... Medications 2. ... differential #diagnosis #causes
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... reactions Common Drugs ... • Digoxin • K ... Medications 2. ... differential #diagnosis #causes
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
Causes of Hyperkalemia ... hyperosmolality - Medications ... to Aldosterone: K ... depletion, - AKI ... Differential #Diagnosis #Causes
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... , RTA Type IV, AI ... only if no clear cause ... Elimination (see Table ... STOP offending medications
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Management Summary Causes ... - Toxins - Drugs ... - Abdominal pain ... declines > ALT) • AKI ... + myoglobin AKI
ACEI or ARB Initiation Hyperkalemia: - Review concurrent drugs - Moderate potassium Intake - Consider: diuretics, sodium
ARB Initiation Hyperkalemia ... Review concurrent drugs ... - Review for causes ... of AKI - Correct ... Reassess concomitant medications
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