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diagnosis rheumatology management differential druginduced sle vasculitis comparison cryoglobulinemia dermatology erythematosus gammopathy mgrs monoclonal petechiae petechial physicalexam rash renal significance
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... Discontinuation of causal ... • Immunologic Workup ... 80% - Low complement
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cause Organ Damage ... • Low serum C4 complement ... (e.g. systemic lupus ... diagnosis #types #classification
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... of SLE versus DIL ... • Immunologic Workup ... Positive in 60-80% of cases ... 80% - Low complement
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... fulminans - DIC ... Autoimmune Vasculitis (lupus ... deficiency Work ... immunoglobulins & cryoglobulins
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... such as systemic lupus ... against MPO • Complement ... Serologies for Cryoglobulins ... #rheumatology #classification
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... : -10% of all lupus ... • Immunologic Workup ... 90% - Low complement ... Discontinuation of causal
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... Diagnostic Workup ... guide subtype classification ... tubulopathy) - Complement ... glomerulopathy) - Cryoglobulin
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