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diagnosis rheumatology differential sle table types vasculitis allergy comparison erythematosus hypersensitivity management reactions systemic champs cryoglobulinemia cryoglobulins druginduced gammopathy glomerulonephritis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... • Immunologic Workup ... 80% - Low complement ... Evolution: Chronic disease
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... involvement: Anti-GBM Disease ... differential #diagnosis #algorithm
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... • Immunologic Workup ... 80% - Low complement ... Evolution: Chronic disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... #rheumatology #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Decade Skin Disease ... Classification: ... RNP antibodies, Complement
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... during hemolytic disease ... Complement activation ... , and systemic lupus ... Hypersensitivity #Types #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
antigens, leading to complement ... reaction, Haemolytic disease ... they activate complement ... glomerulonephritis, Systemic lupus ... allergy #table #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... • Low serum C4 complement ... (e.g. systemic lupus ... diagnosis #types #classification
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
refers to kidney disease ... end-stage kidney disease ... Diagnostic Workup ... guide subtype classification ... tubulopathy) - Complement
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