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diagnosis rheumatology differential classification dermatology petechiae petechial rash anemia associated canca causes cryoglobulinemia cryoglobulins erythematosus glomerulonephritis hemolytic huv hypocomplementemic lupus
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... antibiody -> Immune Complex ... Formation - Complement ... > Incr Immune Complex ... Pathophysiology #Rheumatology
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... Vasculitis A group ... without immune complex ... Complement levels ... PR3 #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tracts Immune Complex ... Urticaria and hypocomplementemia ... Coronary arteries - Fever ... : • Fevers • ... against MPO • Complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
immunofluorescence Immune Complex ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm ... #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Fevers • Fatigue ... and branches • Fever ... pauci-immune GN Immune Complex ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Purpuric Rashes- THE ALGORITHMIC ... petechiae/purpura with fever ... petechiae/purpura with fever ... petechiae require complete ... #Diagnosis #Dermatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... • Low serum C4 complement ... DDX: • ANCA (Antineutrophil ... classification #rheumatology ... #vasculitis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... cardiac valve, vasculitis ... bartonella (oroya fever ... Differential #Diagnosis #Algorithm ... #workup #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... anti-Smith Ab, low complements ... vein thrombosis Hematologic ... to: Arthritis, Fever ... RNP antibodies, Complement
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Differential Diagnosis Algorithm ... Infection - Vasculitis ... Red Flags: • Fever ... deficiency Work ... Up: • Complete
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