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diagnosis rheumatology vasculitis anemia causes lupus renal agglutinin champs clinicopathology cold cryoglobulinemia cryoglobulins dermatology disease disorders eczematous erythematosus gammopathy glomerulonephritis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... 1 (50%-80%), type ... #Low #Complement ... Mnemonic #diagnosis #differential ... #hematology
Lupus Nephritis Classification Algorithm #Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis Classification ... Algorithm #Lupus ... #Algorithm #diagnosis ... #differential # ... types #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... Glomerulonephritis #Vasculitis #differential ... #diagnosis #algorithm ... #rheumatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Diagnosis Algorithm ... Low Mean Corpuscular ... #Anemia #MCV #Classification ... #Causes #Hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... factor level • Low ... serum C4 complement ... #classification ... #rheumatology #
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Diagnosis Algorithm ... B-Cell ~90% • Low ... Lymphoproliferative #Disorders #Classification ... pathophysiology #Hematology ... #algorithm
Eczematous Skin Rash - Differential Diagnosis Algorithm Eczematous - Pruritic/Scaly/Erythematous lesions. Usually poorly demarcated • Atopic Dermatitis
Eczematous Skin Rash - Differential ... Diagnosis Algorithm ... anyone - Allergic ... Very low concentrations ... #Differential #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... #classification
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease 3 Types ... originate from a low-grade ... younger pts) Differential ... temperatures by fixing complement ... hemolytic #anemia #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... Skin Disease Classification ... permanent alopecia Differential ... Kikuchi disease • Type-I
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