11 results
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
C5-C9 Deficiency ... higher in C5-C9 deficiency ... is less severe ... response: The complement ... #pathophysiology
Complement 1 esterase inhibitor (C1-INH) Deficiency Testing Algorithm
INDICATIONS FOR TESTING:
 • Recurrent angioedema (without urticaria)
 •
Complement 1 esterase ... inhibitor (C1-INH) Deficiency ... Testing Algorithm ... #Testing #Algorithm ... #allergy #diagnosis
Tinnitus - Subjective (heard only by patient) - 90% - Differential Diagnosis Algorithm
Unilateral On Audiogram -
Differential Diagnosis Algorithm ... Causes: Thyroid Dysfunction ... Vitamin A, B, Zinc Deficiency ... Conductive Hearing Loss ... Differential #Diagnosis #Algorithm
Anosmia / Smell Dysfunction - Differential Diagnosis Algorithm
Nasal Obstruction/ URTI:
 • Septal Deviation
 • Allergic Rhinitis
Anosmia / Smell Dysfunction ... Differential Diagnosis Algorithm ... Deviation • Allergic ... • Zinc Deficiency ... #Loss #Differential
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
Thiamine Deficiency ... • Increased loss ... and myocardial dysfunction ... - WE + memory loss ... beriberi #nutrition #pathophysiology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... hematologic: Acute blood loss ... Acute hemolysis, deficiency ... post-splenectomy, Exercise, Allergic ... Differential #Diagnosis #Algorithm
SEPSIS AND SEPTIC SHOCK

DEFINITION AND PATHOPHYSIOLOGY
 • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
DEFINITION AND PATHOPHYSIOLOGY ... Life-threatening organ dysfunction ... • Pathophysiology ... NETs), cytokines, complement ... injury: Glycocalyx loss
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... monophasic Pathophysiology ... Autonomic Dysfunction ... not swollen or less ... • Nutritional Deficiency
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm
Structural Defect - Asplenia/HypospIenism
 • Bacteremia/Septic
Differential Diagnosis Algorithm ... or Neutrophil Dysfunction ... Periodontal Disease Complement ... Deficiency • ... Differential #Diagnosis #Algorithm
Pathogenesis of Select Causes of Constipation in Adults and in Elderly

 • Mechanical (ex. Bowel Obstruction,
Thyroid hormone deficiency ... CNS neurons -> Dysfunction ... Evacuation of feces is less ... #constipation #pathophysiology