21 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Allergic Reaction Classification
Type 1 reaction: Acute anaphylactic reaction
Type 2 reaction: Cytotoxic reaction
Type 3 reaction: Immune complex
Type
Allergic Reaction ... Classification ... delayed reaction #Allergic ... #Reaction #Classification ... #Types #allergy
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... Hypersensitivity #Allergy ... #Allergic #Reactions ... #Types #Classification
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... When the specific allergen ... antigen, leading to complement ... Complement activation ... Hypersensitivity #Types #Classification
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
Angioedema - Classification ... Angioedema: • Acute allergic ... exposure • Non-allergic ... or avoiding the allergen ... #Angioedema #Classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... antigens, leading to complement ... they activate complement ... reactions #types #allergy ... #table #classification
Types of hypersensitivity reactions

Type I - lgE-Mediated, Within I Hour (Anaphylaxis)
Type II - IgG or IgM
reactions #Types #Classification ... #Allergy #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... anticoagulant • Complement ... #EULARACR #Classification