11 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... differential #diagnosis #algorithm
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... complement - Rare ... 60-80% - Low ... complement - 50 ... sle #comparison #table
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... Positive in 60-80% of cases ... 60-80% - Low ... complement - 50
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... (Low levels mixed
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
time you have a case ... normal volume-based algorithm ... can be high or low ... differential #diagnosis #table ... #sodium #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Diagnosis and Management ... only if no clear cause ... Elimination (see Table ... acidosis) • Low ... Treatment #potassium #nephrology
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... in >90% - Low ... complement - Rare ... Discontinuation of causal ... diagnosis #treatment #management
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
mental status and low ... the determined cause ... #differential #algorithm ... #management #cardiology ... #treatment #table
Perhaps quite too often, the knee-jerk reaction to an elevated Troponin is to call our friends
are typically able ... treat the primary cause ... may not be the case ... #diagnosis #management ... clinica l#foamed #algorithm