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diagnosis rheumatology differential erythematosus lupus systemic vasculitis cerebritis cns cryoglobulinemia cryoglobulins fever hus immunecompromised immunocompromised management microangiopathy neurology thrombotic tmas
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... is due to TTP, compliment-mediated ... significant renal dysfunction ... catastrophic APS, SRC, SLE ... Microangiopathy #TMAs #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Encephalopathy, Cognitive Dysfunction ... autoantibodies that will cause ... inflammation, leading ... Erythematosus #SLE
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... diagnosis #types #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... mild cognitive dysfunction ... vein thrombosis Hematologic ... RNP antibodies, Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Urticaria and hypocomplementemia ... against MPO • Complement ... vasculitis, and SLE ... #classification
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Differential Diagnosis Algorithm ... or Neutrophil Dysfunction ... Periodontal Disease Complement ... #Causes #Hematology
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