19 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... #Low #Complement ... #differential #hematology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... antigen, leading to complement ... Complement activation ... sclerosis #Hypersensitivity ... #Types #Classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
of hypersensitivity ... Allergen-specific lgE causes ... antigens, leading to complement ... they activate complement ... allergy #table #classification
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... vasculitis • Hypersensitivity ... #classification
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
fibrinolysis (reduces complement ... : Urine Common Uses ... rapid injection; Nausea ... risk of seizures; Hypersensitivity ... #Pharmacology #hematology
Comprehensive pathogenesis of IgA Nephropathy (i.e Berger’s Disease). 

IgA Nephropathy is the most common cause of
the most common cause ... - What type of Hypersensitivity ... Relationship of complement ... PediatricNephrology #Hypersensitivity
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... #classification
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
Hypersensitivity ... cell surfaces causes ... exposure to allergen causes ... #Hypersensitivity ... #Classification
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Caused by splanchnic ... Exclude other AKI causes ... Classification: ... HRS-AKI (formerly Type ... HRS-Non-AKI (formerly Type
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... protein receptor type ... activin A receptor type ... multifactorial mechanisms Hematologic ... #Differential #Causes