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diagnosis management rheumatology differential shock champs cold criticalcare cryoglobulinemia cryoglobulins disease erythematosus gammopathy igg4 low lupus mgrs mnemonic monoclonal proteins
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... 1 (50%-80%), type ... endocarditis (90%) - Dr ... #Low #Complement ... #differential #hematology
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
IgA, RF, CRP Dr ... Proteins #Subtypes #algorithm ... #classification ... #Types #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... Types: • Type ... • Low serum C4 complement ... #classification ... #rheumatology #
Shock Types - Classification State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
Shock Types - Classification ... END-ORGAN DYSFUNCTION ... - Most common type ... Hemorrhagic → leading ... water #Shock #Classification
Shock Classification Shock Definition: State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
Shock Classification ... END-ORGAN DYSFUNCTION ... • Most common type ... Hemorrhagic → leading ... #Types #diagnosis
Von Willebrand Disease Classification Type 1 (Accounts for ~3/4 of cases): • Defect: Quantitative defect (i.e. not
Willebrand Disease Classification ... Qualitative defect (i.e. dysfunctional ... hemophilia A) - Dr ... VonWillebrand #Disease #Classification ... #hematology
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... progressive organ dysfunction ... • Pancreas: Type ... - ↑ IgE, ↓ complement ... • Classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... Malignancy (e.g. hematologic ... Kikuchi disease • Type-I ... mild cognitive dysfunction
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
meet criteria for hematologic ... Proteinuria >1.5 g/day ... guide subtype classification ... tubulopathy) - Complement ... vasculitis Types
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