14 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... glomerulonephritis (>90%) S - Systemic ... #Low #Complement
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... arthritis, and systemic ... #Classification ... #Pathophysiology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... hematological disorders ... • Low serum C4 complement ... (e.g. systemic ... #classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of types ... antigens, leading to complement ... they activate complement ... glomerulonephritis, Systemic ... allergy #table #classification
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... protein receptor type ... activin A receptor type ... heart disease Systolic ... , lenectomy Systemic
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... site in lymphatic system ... with lymphatic system ... #Classification ... #pathophysiology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... central nervous system ... against MPO • Complement ... #rheumatology #classification
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the electrical system of the heart that
one of several disorders ... the electrical system ... resulting in a unique type ... #Pathophysiology
Restrictive Cardiomyopathy - Diagnosis and Causes
Clinical: Dyspnea, Exercise Intolerance, ↑ "Right Sided-Symptoms" (ascites, hepatomegaly, ↑↑peripheral edema)
Physical
Amyloid, Wild Type ... Mucopolysaccharidosis Type ... Cardiomyopathy, Systemic ... Sarcomeric Protein Disorders ... differential #cardiology #algorithm
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I ... RNP antibodies, Complement