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diagnosis rheumatology differential lupus sle comparison erythematosus hematology types allergy champs clinicopathology criteria cryoglobulinemia cryoglobulins disorders druginduced eularacr gi glomerulonephritis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... #rheumatology #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low ... Complement: Post-strep ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... > 0.5 g/24 hr, Class ... lupus nephritis, Class ... anticoagulant • Complement
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... factor level • Low ... serum C4 complement ... disorder (e.g. systemic ... diagnosis #types #classification
Causes of ileitis beyond Crohn’s disease and infections include systemic disorders -spondyloarthropathies, vasculitides, ischemia, and amyloidosis
Causes of ileitis ... infections include systemic ... spondyloarthropathies, vasculitides ... See below for table ... helpful paper complements
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Allergen-specific lgE causes ... glomerulonephritis, Systemic ... types #allergy #table ... #classification
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
site in lymphatic system ... with lymphatic system ... are present • Classic ... B-Cell ~90% • Low ... Lymphoproliferative #Disorders #Classification
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... complement - Rare ... months to years) Systemic ... complement - 50 ... sle #comparison #table
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low ... complements and ... Skin Disease Classification ... , lymphopenia, low
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