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diagnosis differential nephrology rheumatology management allergy glomerulonephritis hypersensitivity pathophysiology vasculitis nephrotic reactions table workup acidosis comparison criticalcare dementia diabetes disease
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... Their Mechanisms Type ... antigen, leading to complement ... Complement activation ... #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of types ... Allergen-specific lgE causes ... antigens, leading to complement ... they activate complement ... allergy #table #classification
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
with evidence of glomerular ... immune deposits in glomeruli ... post-infectious GN Anti-Glomerular ... autoAb against type ... Glomerulonephritis #RPGN #Classification
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... formation along glomerular ... staining (lg + complement ... MGPN • Complement ... of alternative complement
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
Glomerular Diseases ... RBC casts in urine ... but in severe cases ... diabetes)) #Glomerular ... Nephrotic #Syndromes #Classification
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... or alternative complement ... infections are common causes ... of glomerular disease ... cryoglobulinemias (types
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Types: • Type ... • Low serum C4 complement ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Vasculitis - Skin, glomeruli ... : - Kidneys: glomerular ... against MPO • Complement ... #rheumatology #classification
Atlas of Urine Microscopy Findings • Epithelial cells - Normal • Renal tubular cells - Acute
red - cells Non-glomerular ... Dysmorphic red cells - Glomerular ... Diagnostic of glomerular ... • White cell casts ... - Any type of renal
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