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diagnosis rheumatology differential glomerulonephritis nephrology rpgn vasculitis erythematosus gammopathy glomerular igg4 management mgrs monoclonal nephritic nephrotic rapidly renal significance sle
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome: - Acute poststreptococcal glomerulonephritis - Rapidly progressive
Glomerular Diseases ... glomerulonephritis - Rapidly progressive ... Minimal change disease ... Both - Diffuse ... #Syndromes #Classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive ... Post-strep GN, Lupus ... Nephritis, Cryoglobulinemia ... involvement: Anti-GBM Disease ... differential #diagnosis #algorithm
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Classification: ... pneumonitis • Diffuse ... enteropathy, and diffuse ... RNP antibodies, Complement
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Rapidly Progressive ... of glomerular disease ... IgA nephropathy, lupus ... nephritis, cryoglobulinemia ... Glomerulonephritis #RPGN #Classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... #rheumatology #classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... inflammation -> progressive ... Tubulointerstitial nephritis ... - ↑ IgE, ↓ complement ... • Classification
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
refers to kidney disease ... Clinical Clues: • Nephrotic-range ... guide subtype classification ... tubulopathy) - Complement ... function and prevent progression
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