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diagnosis differential rheumatology vasculitis erythematosus hematology sle causes champs criteria cryoglobulins disorders eularacr glomerulonephritis high hyperkalemia lymphomas lymphoproliferative mnemonic nonhodgkin
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Mnemonic C - Cryoglobulinemia ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... #Low #Complement
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... anticoagulant • Complement ... #EULARACR #Classification ... Criteria #SLE #Systemic
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... , Cryoglobulinemia ... differential #diagnosis #algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... factor level • Low ... serum C4 complement ... lupus erythematosus ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
lupus erythematosus ... against MPO • Complement ... (Low levels mixed ... cryoglobulinemia ... #rheumatology #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low ... complements and ... Skin Disease Classification ... , lymphopenia, low
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
site in lymphatic system ... with lymphatic system ... lymphadenopathy more diffuse ... B-Cell ~90% • Low ... Lymphoproliferative #Disorders #Classification
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
neuromuscular injury, disuse ... Tubulointerstitial diseases: syßtemic ... lupus erythematosus ... Drug-associated: heparin, low-molecular-weight ... High #Potassium #Classification
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