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diagnosis rheumatology differential management erythematosus systemic vasculitis druginduced champs clinicopathology comparison criteria cryoglobulinemia cryoglobulins dil eularacr glomerulonephritis hematology high hyperkalemia
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Lupus Nephritis Primer Class I - Minimal Mesangial Class II - Mesangial Proliferative Class Ill - Focal Proliferative Class IV
Lupus Nephritis ... IV - Diffuse Proliferative ... #Nephritis #SLE ... #Classification ... #Classes #differential
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... > 0.5 g/24 hr, Class ... , Class Ill or IV ... anticoagulant • Complement ... #Criteria #SLE
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... in >90% - Low ... complement - Rare ... Positive in 60-80% of cases ... complement - 50
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... 60-80% - Low ... complement - 50
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... differential #diagnosis #algorithm
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low ... complements and ... Skin Disease Classification ... , lymphopenia, low
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... against MPO • Complement ... (Low levels mixed ... vasculitis, and SLE ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... factor level • Low ... serum C4 complement ... (e.g. systemic lupus ... diagnosis #types #classification
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
cases, drug-dependent ... is rare in DIL, SCLE-DIL ... in >90% - Low ... complement - Rare ... Discontinuation of causal
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