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diagnosis differential rheumatology causes hemoptysis renal classification erythematosus glomerulonephritis mimics nephrology progressive rapidly rpgn sle syndrome syndromes systemic vasculitides
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
Massive Hemoptysis ... • Bronchitis Diffuse ... Vasculitis • ... Lupus Erythematosus ... #Massive
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... Diagnosis Framework Diffuse ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... Kumfer @AnnKumfer #Pulmonary
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... With associated pulmonary ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Definition: Diffuse ... ANCA-positive vasculitis ... ANCA-negative vasculitis ... Complex: Systemic lupus ... anti-CCP • CXR (diffuse
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... ANCA-associated vasculitis ... pneumonitis • Diffuse ... enteropathy, and diffuse ... RNP antibodies, Complement
Hemoptysis - Differential Diagnosis Framework Massive Hemoptysis: >150-300 mL in 24h Airway disease: • Bronchitis, Bronchiectasis, Malignancy
Diagnosis Framework Massive ... Autoimmune: ANCA-Assoc vasculitis ... Vascular: • Diffuse ... Differential #Diagnosis #pulmonary
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