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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
inflammation Others: • Lupus ... lupus erythematosus ... against MPO • Complement ... , and SLE) • Urinalysis ... #rheumatology #classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... anticoagulant • Complement ... #Criteria #SLE ... #Systemic #Lupus
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... RNP antibodies, Complement ... #Systemic #Lupus
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... 90% - Low complement ... months to years) Systemic ... 80% - Low complement ... #table #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Low serum C4 complement ... lupus erythematosus ... (SLE), rheumatoid ... diagnosis #types #classification
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... (SLE): ANA (anti-nuclear ... • Scleroderma (Systemic ... Polymerase Ill • ANCA Vasculitis ... #associations #table
Causes of ileitis beyond Crohn’s disease and infections include systemic disorders -spondyloarthropathies, vasculitides, ischemia, and amyloidosis
infections include systemic ... spondyloarthropathies, vasculitides ... See below for table ... helpful paper complements ... #Differential #Table
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... lupus erythematosus ... Hypersensitivity #Types #Classification ... Diagnosis #Reactions #Table
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... glomerulonephritis, Systemic ... lupus erythematosus ... types #allergy #table ... #classification