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diagnosis differential rheumatology causes classification arthropathies arthropathy cardiology champs cryoglobulinemia cryoglobulins diseases disorders erythematosus glomerulonephritis hematology ild inflammatory interstitial joint
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... lupus erythematosus ... against MPO • Complement
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
Differential Diagnosis Algorithm ... Lupus - with Systemic ... Lupus Erythematosus ... Joint #Disorders #msk ... Differential #Diagnosis #Algorithm
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Low serum C4 complement ... • Vasculitis ... disorder (e.g. systemic ... lupus erythematosus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... RNP antibodies, Complement
Causes of Pericarditis - Differential Diagnosis Algorithm Viral: • Coxsackie • Echovirus • Adenovirus • Epstein-Barr virus
Differential Diagnosis Algorithm ... arthritis • Systemic ... lupus erythematosus ... spondyloarthropathies • Vasculitis ... Differential #Diagnosis #Algorithm
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
Differential Diagnosis Algorithm ... Arthritis • Systemic ... Lupus Erythematosus ... Inflammatory #JointPain #MSK ... Differential #Diagnosis #Algorithm
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm Idiopathic Interstitial Pneumonia • (UIP) Usual Interstitial Pneumonia
Differential Diagnosis Algorithm ... Rheumatoid Arthritis, Systemic ... Lupus and Scleroderma ... Amy Chung, MD, MSc ... Differential #Diagnosis #Algorithm
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... Central nervous system ... ) • Cutaneous vasculitis ... Vasculitis: • ... phenomenon (16%) MSK
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