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diagnosis rheumatology lupus comparison differential erythematosus table vasculitis allergy cardiology criteria druginduced endocarditis eularacr hypersensitivity reactions summary types vasculitides
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... and Management ... Positive in 60-80% of cases ... 80% - Low complement ... #lupus #Systemic
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... Constitutional domain: Fever ... anticoagulant • Complement ... #Criteria #SLE
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
10% of all lupus cases ... 90% - Low complement ... Discontinuation of causal ... months to years) Systemic ... Positive in 60-80% of cases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Vasculitis: • Fevers ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Allergen-specific lgE causes ... Anaphylaxis, Hay fever ... they activate complement ... glomerulonephritis, Systemic ... allergy #table #classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Vasculitis: • Fevers ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
• Autoimmune (SLE ... positive in 90% of IE cases ... night sweats, fever ... Septic Emboli Cause ... Endocarditis #diagnosis #management
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