40 results
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Eosinophilia, asthma, chronic ... tract, and often causes ... Urticaria and hypocomplementemia ... against MPO • Complement ... , and SLE) • Urinalysis
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... Discontinuation of causal ... • Immunologic Workup ... • Evolution: Chronic
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... • Immunologic Workup ... Positive in 60-80% of cases ... 80% - Low complement ... • Evolution: Chronic
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Causes of Diffuse Lung Disease. 
Collagen vascular 
 - Scleroderma 
 - Rheumatoid arthritis 
 -
Causes of Diffuse ... Dermatomyositis - SLE ... - Toxic gas Vasculitides ... Infectious - Chronic ... #Differential #Causes
Causes of Approach to Altered Level of Consciousness - Workup
Clinical Exam - Focal
 • Trauma
 •
Causes of Approach ... Consciousness - Workup ... Hemorrhage • See ... Refer to Blood Work ... #algorithm #Causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Autoimmune • ITP • SLE ... HUS • DIC • Vasculitis ... #Causes #Hematology
Causes of Peripheral Weakness with Sensory Changes - Differential Diagnosis Algorithm
Radiculopathy:
 • Disc
 • Spondylosis
 •
Causes of Peripheral ... Differential Diagnosis Algorithm ... Multiplex: • Vasculitis ... Spondylysis • Chronic ... #Causes
Causes of Polyneuropathy - Differential Diagnosis Algorithm
 • Metabolic: DM, Hypothyroidism, CKD, Cirrhosis, Nutritional deficiency
 •
Causes of Polyneuropathy ... Differential Diagnosis Algorithm ... Paraneoplastic, CTD (SLE ... RA, Sjogren’s), Vasculitis ... #causes #neurology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... diseases: - 10% SLE ... • Low serum C4 complement ... erythematosus (SLE