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diagnosis differential rheumatology acute aki causes injury nephrology cryoglobulinemia cryoglobulins ddxof erythematosus gammopathy glomerulonephritis igg4 im large lupus management medium
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Urticaria and hypocomplementemia ... Polyarteritis Nodosa: - Kidneys ... Kidneys -> glomerulonephritis ... against MPO • Complement ... #rheumatology #classification
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... Diagnosis #IM #Rheum #Vasculitis ... #Vessel #Size #Classification ... #ANCA #Differential ... #Algorithm #Ddxof
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... • Limited to Kidney ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
musculoskeletal systems • Kidneys ... : ANCA Associated ... Pauci Immune (ANCA ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... Emboli, Thrombosis, Vasculitis ... • GN: ANCA, Anti-GBM ... #AKI #Acute #Kidney ... nephrology #causes #algorithm
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... - AKI Workup Algorithm ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM ... #AKI #Workup #Algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... DDX: • ANCA (Antineutrophil ... • IgA vasculitis ... • Vasculitis ... diagnosis #types #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... RNP antibodies, Complement ... C4) • ds-DNA: Kidney ... induced SLE • Kidney
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
aortitis, mimics vasculitis ... • Kidneys: Tubulointerstitial ... - ↑ IgE, ↓ complement ... • Classification
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
MGRS refers to kidney ... damage, especially kidneys ... guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis
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