12 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Post-strep GN, Lupus Nephritis ... • Limited to Kidney ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... Urticaria and hypocomplementemia ... Polyarteritis Nodosa: - Kidneys ... Kidneys -> glomerulonephritis ... against MPO • Complement
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... - AKI Workup Algorithm ... and Differential Diagnosis ... Glomerulonephritis / Vasculits ... • Interstitial nephritis
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... for ANCA-related vasculitis ... #glomerular #testing ... #workup #diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Differential Diagnosis ... C4) • ds-DNA: Kidney ... induced SLE • Kidney ... Erythematosus #Diagnosis
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
PET-CT Imaging (→ Diagnostic ... lesions, meninges, kidneys ... rheumatoid factor), ± hypocomplementemia ... No necrosis, No vasculitis ... management #phenotypes #workup
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle ... cardiac valve, vasculitis ... #Algorithm #workup ... #hematology #testing
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
or alternative complement ... for ANCA-related vasculitis ... glomerular #disease #workup ... #diagnosis #initial ... #nephrotic #nephritis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Algorithm Peripheral ... hematology for workup ... Rheumatologic, Vasculitides ... disease, Kawasaki, Nephrotic
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
myalgia, serositis, Kidney ... • Immunologic Workup ... ulcers, Lupus nephritis ... • Immunologic Workup ... #rheumatology #diagnosis