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diagnosis differential rheumatology nephrology acute aki injury kidney workup dermatology glomerular glomerulonephritis large medium nephrotic nonpalpable palpable purpura size testing
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... #Small #Medium ... #Vessel #Size #Classification ... #ANCA #Differential ... #Algorithm #Ddxof
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
abnormalities SMALL ... tract, and often causes ... pain, infarct • Small ... against MPO • Complement ... #rheumatology #classification
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... Vasculitis A group ... of necrotizing, small-vessel ... vasculitis without ... Complement levels
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
, and small vessel ... Small vessel vasculitis ... immune complex small ... basement membrane; ANCA ... Medium #Large #Classification
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... Vasculitis Vasculitis ... of small vessels ... - ANCA-associated ... dermatomyositis #Size #Classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
and infarcts SMALL ... : ANCA Associated ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... Leukocytoclastic Vasculitis ... cryoglobulins, IgA), ANCA ... associated small ... nonpalpable #palpable #Causes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Low serum C4 complement ... DDX: • ANCA (Antineutrophil ... • Cutaneous small-vessel ... diagnosis #types #classification
Vascular Skin Lesions - Differential Diagnosis Algorithm - Petechiae < 0.2 cm diameter - Purpura 0.2
Differential Diagnosis Algorithm ... with Pressure - Small ... • Acquired - Vasculitis ... #Vascular #Vasculitis ... #causes
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