13 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitis and Vasculitides ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... neuropathy - GI ... against MPO • Complement
Causes of ileitis beyond Crohn’s disease and infections include systemic disorders -spondyloarthropathies, vasculitides, ischemia, and amyloidosis
spondyloarthropathies, vasculitides ... See below for table ... helpful paper complements ... of our GI fellow ... #Differential #Table
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... nausea, vomiting, GI ... #HSP #IgA #Vasculitis ... HenochScholeinPurpura #Pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... When to Consider Vasculitis ... mononeuritis multiplex • GI ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Highlighted Conditions With Arteritis or Periarteritis of the Coronaries
Takayasu's arteritis:
 - Onset < 40 yrs
 -
multiplex ANCA vasculitis ... Leukocytoclastic vasculitis ... - Ulceration GI ... Diagnosis #Cardiology #Table
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
or swelling - GI ... Non-specific abdo pain, GI ... PolyarteritisNodosa #Pathophysiology ... Signs #Symptoms #Vasculitis
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Classification #Pathophysiology ... Diagnosis #Reactions #Table
Mechanisms of Cocaine induced AKI

 • Rhabdomyolysis
 • Vasculitis
 • Infarction
 • Acute interstitial nephritis
 •
Rhabdomyolysis • Vasculitis ... AKI #nephrology #pathophysiology ... #table