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diagnosis management rheumatology differential lupus druginduced sle champs classification comparison criticalcare dil disease erythematosus foamed gammopathy hematology igg4 mgrs mnemonic
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
pseudotumor 4 phenotypes ... with response to treatment ... rheumatoid factor), ± hypocomplementemia ... diagnosis #management #phenotypes ... #workup #treatment
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... in >90% - Low ... complement - Rare ... 60-80% - Low ... complement - 50
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
• Immunologic Workup ... 60-80% - Low ... complement - 50 ... life-threatening • Treatment
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
which all carry treatment ... hormones that work ... both conditions, low ... #differential #algorithm ... #management #treatment
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
• Immunologic Workup ... in >90% - Low ... complement - Rare ... constitutional symptoms • Treatment ... rheumatology #diagnosis #treatment
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Diagnostic Workup ... Pathogenesis: How ... Damages Kidneys • Low ... tubulopathy) - Complement ... microangiopathy Treatment
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