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diagnosis rheumatology differential glomerular glomerulonephritis nephrology nephrotic testing workup classification disease erythematosus gammopathy hematology huv initial lupus management mgrs mnemonic
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... - CHAMPS Mnemonic ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... #CHAMPS #Mnemonic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... Formation -> Vasculitis ... TerrierBen #Hypocomplementemic
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
in monitoring low-level ... or alternative complement ... for ANCA-related vasculitis ... glomerulonephritis #nephrotic ... #nephritic #nephrology
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
in monitoring low-level ... or alternative complement ... for ANCA-related vasculitis ... testing #nephrology #nephrotic ... #nephritis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... ANCA-associated vasculitis ... , lymphopenia, low ... RNP antibodies, Complement
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... ) • Cutaneous vasculitis ... • Interstitial nephritis ... : 2% Systemic Vasculitis
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Clinical Clues: • Nephrotic-range ... Pathogenesis: How ... Damages Kidneys • Low ... tubulopathy) - Complement ... formation causing vasculitis
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