23 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... involvement: Anti-GBM Disease ... differential #diagnosis #algorithm
Workup of Hypercalcemia - Differential Diagnosis Algorithm
High or Normal PTH:
 • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia,
Workup of Hypercalcemia ... Differential Diagnosis Algorithm ... Hypercalcemia Low ... PTHrP: - Low ... #Workup #nephrology
Hyperthyroidism (low TSH, High T4/T3) - Diagnostic Algorithm

Radioactive iodine scan – get if concern for nodular
Hyperthyroidism (low ... ) - Diagnostic Algorithm ... affects diagnostic workup ... Hyperthyroid #Diagnosis #Algorithm ... #Workup #Endocrinology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... (Granulomatous disease ... against MPO • Complement ... (Low levels mixed
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
ulcers, Lupus nephritis ... • Immunologic Workup ... 60-80% - Low ... complement - 50 ... Evolution: Chronic disease
Hypocalcemia - Differential Diagnosis Algorithm - Low and High Phosphate
LOW PHOSPHATE
 - Low/NormaI PTH
Differential Diagnosis Algorithm ... Malabsorption, Phenytoin, Nephrotic ... Hepatobiliary Disease ... Chronic Kidney Disease ... Differential #Diagnosis #Algorithm
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... (nephrotic-range ... , lymphopenia, low ... RNP antibodies, Complement
Suggested diagnostic approach to a patient with exudative ascites. Low ascitic fluid protein should direct practitioners
Low ascitic fluid ... practitioners to rule out nephrotic ... obstruction, nephrotic ... ascites #diagnosis #workup ... #algorithm #differential
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... rheumatoid factor), ± hypocomplementemia ... IgG4 #Related #Disease ... management #phenotypes #workup