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diagnosis rheumatology differential management lupus vasculitis druginduced sle champs classification comparison coronavirus covid19 dil erythematosus glomerulonephritis guide immunecompromised immunocompromised mnemonic
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... #differential #hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low ... Complement: Post-strep ... differential #diagnosis #algorithm ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Positive in 60-80% of cases ... 60-80% - Low ... complement - 50 ... management of SLE • Evolution ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... complement - Rare ... 60-80% - Low ... complement - 50 ... comparison #table #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis: • Fevers ... and branches • Fever ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
UCSF COVID-19 Adult Clinical Evaluation Guide - Updated April 10 2020 Clinical Presentation • Fever: hospitalized pts but
Adult Clinical Evaluation ... Presentation • Fever ... Cardiac: multiple case ... normal, can be low ... Guide #Diagnosis #Algorithm
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Differential Diagnosis Algorithm ... Periodontal Disease Complement ... Infection #Fever ... #Causes #Hematology
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
disease of unknown cause ... symptoms may include low-grade ... fevers, anorexia ... • An evaluation ... with significant fevers
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
in >90% - Low ... complement - Rare ... Discontinuation of causal ... cutaneous-DIL • Evolution ... DrugInduced #Lupus #DIL #rheumatology
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